Dr. Bonetto completed his MSc in Industrial Biotechnology and PhD in Experimental Pathology at University of Torino, Italy. During his postdoctoral training at University of Miami and Thomas Jefferson University, Dr. Bonetto worked on unraveling the mechanisms of muscle wasting in the occurrence of cancer, with particular focus on the role of the pro-inflammatory IL-6/STAT3 signaling pathway.
After joining Indiana University for his first faculty appointment, he contributed to develop new models for the study of cachexia in ovarian and colorectal cancers. As an independent investigator, Dr. Bonetto developed interests towards understanding the effects of chemotherapy in muscle and bone, as well as on the whole-body energy metabolism, with the goal of identifying therapeutic strategies to reduce the side toxicity of anticancer treatments.
Currently, Dr. Bonetto is an Associate Professor in the Department of Pathology at University of Colorado Anschutz Medical Campus and is primarily interested in investigating the liver-bone-muscle interactions in a setting of cancer. The Bonetto Lab has identified secreted factors playing a critical role in the tumor-host interaction and driving muscle and bone dysfunctions in subjects affected with cancer. Since 2006, Dr. Bonetto has authored over 65 publications and more than 120 communications/presentations to national and international meetings. His laboratory has been continuously funded by grants from NIH (NCI, NIAMS), American Cancer Society and V Foundation for Cancer Research.
Dr. Bonetto is a member of the University of Colorado Comprehensive Cancer Center Tumor-Host Interactions Program and serves as mentor within the Cancer Biology, Integrated Physiology and Biomedical Science Training Programs. He is the Leader of the Skeletal Muscle Working Group of the Nutrition Obesity Research Center (NORC) at University of Colorado. He is a member of the American Association for Cancer Research (AACR), the American Physiological society (APS), the American Society for Bone and Mineral Research (ASBMR), and the Society on Sarcopenia, Cachexia and Wasting Disorders (SCWD). Dr. Bonetto is the former co-chair of the Education Committee of the Cancer Cachexia Society (CCS), and currently served as Associate Editor of the Journal of Cachexia Sarcopenia and Muscle, and Editor of the 'Muscle and Bone' section of Current Osteoporosis Reports.